Fig. 2.

Effects of muramyl peptides and lipopolysaccharide (LPS) on respiration rates and respiratory control ratio (RCR) in rat liver mitochondria in vitro. Oxygen consumption was measured in the presence of (a) 100 µM muramyl dipeptide (MDP), (b) 100 µM murabutide (MB) and (c) 100 µM of muramyl peptides and 50 µg/ml of LPS after 2 min of incubation. Data were normalized (closed bars) to the state 3 rates as in (a) and (b) and to 1 as in (c) of control mitochondria. Data are means ± standard error of the mean of three independent experiments each performed in triplicate. *P < 0·05.