. Author manuscript; available in PMC: 2009 Nov 21.

Published in final edited form as: Toxicology. 2008 Sep 4;253(1-3):79–88. doi: 10.1016/j.tox.2008.08.014

Table 6.

Cytoplasmic vacuolization of hepatocytes in mice

	Dose (mg/kg) (AAC, AAL, ACR)	Allyl Acetate	Allyl Alcohol	Acrolein

Male
	0	0/10	0/10	0/10
	8, 3, 1.25	0/10	0/10	0/10
	16, 6, 2.5	0/10	0/10	0/10
	32, 12, 5	0/10	0/10	0/10
	62.5, 25, 10	6/10^**(1.0)	2/10(1.0)	0/10
	125, 50, 20	0/10	10/10^**(1.0)	0/10
Female
	0	0/10	1/10(1.0)	0/10
	8, 3, 1.25	0/10	1/10(1.0)	0/10
	16, 6, 2.5	0/10	1/10(1.0)	0/10
	32, 12, 5	3/10(1.0)	5/10(1.0)	0/10
	62.5, 25, 10	4/10^*(1.3)	8/10^**(1.0)	0/10
	125, 50, 20	0/10	9/10(1.2)	0/10

Significantly different (P ≤ 0.05) from the vehicle control group by Fischer exact test

^**

P ≤ 0.01