Table 6.
Cytoplasmic vacuolization of hepatocytes in mice
Dose (mg/kg) (AAC, AAL, ACR) |
Allyl Acetate |
Allyl Alcohol |
Acrolein | |
---|---|---|---|---|
Male | ||||
0 | 0/10 | 0/10 | 0/10 | |
8, 3, 1.25 | 0/10 | 0/10 | 0/10 | |
16, 6, 2.5 | 0/10 | 0/10 | 0/10 | |
32, 12, 5 | 0/10 | 0/10 | 0/10 | |
62.5, 25, 10 | 6/10**(1.0) | 2/10(1.0) | 0/10 | |
125, 50, 20 | 0/10 | 10/10**(1.0) | 0/10 | |
Female | ||||
0 | 0/10 | 1/10(1.0) | 0/10 | |
8, 3, 1.25 | 0/10 | 1/10(1.0) | 0/10 | |
16, 6, 2.5 | 0/10 | 1/10(1.0) | 0/10 | |
32, 12, 5 | 3/10(1.0) | 5/10(1.0) | 0/10 | |
62.5, 25, 10 | 4/10*(1.3) | 8/10**(1.0) | 0/10 | |
125, 50, 20 | 0/10 | 9/10(1.2) | 0/10 |
Significantly different (P ≤ 0.05) from the vehicle control group by Fischer exact test
P ≤ 0.01