Table 7.

Urinary S-(3-hydroxypropyl) mercapturic acid concentration^a in F344 rats following administration of 1^st and 45^th dose (n=10/dose group)

Dose (mg/kg) (AAC, AAL, ACR)		Allyl Acetate	Allyl Alcohol	Acrolein
	Males
0	1st	----b	---- b	--- b
6, 1.5, 0.75	1st	17.66±1.10**	13.42±0.63**	13.82±0.94**
12, 3, 1.25	1st	51.83±5.28**!	22.33±0.96**	18.41±0.80**
25, 6, 2.5	1st	126.09±8.08**	54.17±3.23**!	32.64±1.82**
50, 12, 5	1st	355.10±15.76**#	103.25±6.00**	60.65±3.39**
100, 25, 10	1st	---- c	239.20±18.73**#	63.85±9.45**
0	45th	---- b	---- b	---- b
6, 1.5, 0.75	45th	57.25±2.74**	19.59±1.10**	18.56±1.61**
12, 3, 1.25	45th	104.43±8.34**!	37.38±2.68**	24.07±1.48**
25, 6, 2.5	45th	260.00±18.61**	77.74±4.81**!	42.80±3.02**e
50, 12, 5	45th	479.70±33.78**#	140.10±17.59**d	69.61±3.51**
100, 25, 10	45th	---- c	354.40±29.12**#	44.30±18.50**f
	Females
0	1st	---- b	---- b	--- b
6, 1.5, 0.75	1st	18.63±1.91**	13.08±0.75**	12.60±1.22**d
12, 3, 1.25	1st	63.87±3.77**!	21.03±0.82**	17.08±1.39**
25, 6, 2.5	1st	147.94±17.42**	44.47±2.39**!	31.81±2.46**
50, 12, 5	1st	335.20±33.13**#	100.22±7.07**	52.17±3.68**
100, 25, 10	1st	---- c	249.13±24.90**#	73.92±8.15**
0	45th	---- b	---- b	---- b
6, 1.5, 0.75	45th	33.33±2.56**	16.91±1.14**	11.09±0.55**
12, 3, 1.25	45th	73.60±4.17**!	36.83±2.14**	19.34±1.82**d
25, 6, 2.5	45th	162.92±17.88**	93.58±7.12**!	26.56±2.90**e
50, 12, 5	45th	380.40±36.09**#	183.40±18.49**	49.22±7.15**d
100, 25, 10	45th	---- c	453.80±26.66**#	98.20g

^**Significantly different (P≤0.01) from vehicle control group by Shirley’s test

^!Significantly different (P≤0.01) from 5.0 mg/kg acrolein (approximate equimolar dose comparison) by unpaired t-test

^#Significantly different (P≤0.01) from 5.0 mg/kg acrolein (MTD) by unpaired t-test

^aData are presented as µg/mL of urine (mean ± standard deviation)

^bBelow the limit of detection (1.30 µg/mL)

^cNo data available due to 100% mortality

^dn=9

^en=8

^fn=2

^gn=1