Figure 3.

Cytotoxicity of AAD CTL lines against endogenously expressed protein after stimulation with the core-specific peptides 1073.07, C7A2, and 939.20.1 6 mo after immunization with AC7. C1R-AAD target cells were infected for 2 hr with rVV expressing HCV-core or measles HA as a control, at a multiplicity of infection of 10, washed, incubated for an additional 14 hr, and then ⁵¹Cr labeled. Lysis by the CTL lines stimulated with each of the three peptides is shown as a function of effector-to-target ratio, with 3,000 target cells per well.