Figure 4.
Vaccinia virus titers in ovaries of mice challenged with 107 pfu of vaccinia/HCV-core or vaccinia/measles HA i.p. 2 mo after immunization. Two months after immunization with either the AC7 HCV-core DNA vaccine or mock DNA vaccine (plasmid only), the mice were challenged i.p. with 1 × 107 pfu of rVV expressing HCV-core or measles HA as a control. In the groups indicated, the mice were treated with 0.5 mg anti-CD8 antibody daily for 2 d before challenge, on the day of challenge, and on the day after challenge. Five days after challenge, the ovaries were harvested and the vaccinia titer measured by plaquing on BSC-1 cells. Two independent experiments are shown in a and b.