Figure 5.
Titer of vaccinia/HCV-core in ovaries of mice 6 mo after immunization. Six months after immunization with the indicated DNA vaccines, mice were challenged as described in Fig. 4. There was a statistically significant protection with a 7-log10 reduction in virus titer in the group immunized with AC7 and not treated with anti-CD8 antibody, compared with mice immunized with AC7 and treated with anti-CD8 antibody (P = 0.000057 by Student's t test). Thus, protection persisted 6 mo after immunization and was CD8 dependent.