Figure 6.
Titer of vaccinia/HCV-core in ovaries of mice 14 mo after immunization. Fourteen months after immunization with AC7 or mock DNA vaccines, mice were challenged with HCV-core rVV, as indicated in Fig. 4. There was a statistically significant protection with a 5-log10 reduction in virus titer in the group immunized with AC7 and not treated with anti-CD8 antibody, compared with mice immunized with AC7 and treated with anti-CD8 antibody (P = 0.0000015 by Student's t test). Thus, protection persisted at least 14 mo after immunization and was CD8 dependent.