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. 2009 Mar;174(3):746–761. doi: 10.2353/ajpath.2009.080658

Table 1.

Common Gene Expression Changes in Human Breast CAFs and Cav-1−/− MSFs

A. Genes up-regulated in both human breast CAFs and Cav-1−/− MSFs (55 genes)
Symbol Gene name Fold-upregulation in Cav-1 KO
Anln Anillin, actin binding protein (scraps homolog, Drosophila) 2.5
Aurka Aurora kinase A 3.3
Birc5 Baculoviral IAP repeat-containing 5 (survivin) 3.8
Blm Bloom syndrome 2.0
Brca1 Breast cancer 1, early onset 2.3
Bub1 BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 3.6
Bub1b BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) 2.5
Casc5 Cancer susceptibility candidate 5 2.5
Ccnb2 Cyclin B2 2.3
Ccnf Cyclin F 2.1
Cdc20 CDC20 cell division cycle 20 homolog (S. cerevisiae) 2.4
Cdc45l CDC45 cell division cycle 45-like (S. cerevisiae) 2.0
Cdca1 Cell division cycle associated 1 2.4
Cdca3 Cell division cycle associated 3 2.7
Cdca5 Cell division cycle associated 5 2.1
Cdca8 Cell division cycle associated 8 3.0
Cenpa Centromere protein A 3.9
Cenpf Centromere protein F, 350/400ka (mitosin) 2.8
Cenpk Centromere protein K 2.0
Cep55 Centrosomal protein 55kDa 3.2
Ckap2l Cytoskeleton associated protein 2-like 2.5
Dlg7 Discs, large homolog 7 (Drosophila) 2.6
E2f7 E2F transcription factor 7 2.7
Fabp5 Fatty acid binding protein 5 (psoriasis-associated) 3.9
Foxm1 Forkhead box M1 2.4
Hmmr Hyaluronan-mediated motility receptor (RHAMM) 3.3
Kif11 Kinesin family member 11 2.7
Kif20a Kinesin family member 20A 2.8
Kif23 Kinesin family member 23 2.5
Kif2c Kinesin family member 2C 3.3
Kntc2 Kinetochore associated 2 2.6
Mad2l1 MAD2 mitotic arrest deficient-like 1 (yeast) 2.3
Mcm10 MCM10 minichromosome maintenance deficient 10 (S. cerevisiae) 2.4
Mcm5 MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) 3.8
Melk Maternal embryonic leucine zipper kinase 2.3
Mki67 Antigen identified by monoclonal antibody Ki-67 3.1
Nek2 NIMA (never in mitosis gene a)-related kinase 2 2.0
Nusap1 Nucleolar and spindle associated protein 1 3.1
Oip5 Opa interacting protein 5 2.0
Pbk PDZ binding kinase 2.7
Plk1 Polo-like kinase 1 (Drosophila) 3.2
Prc1 Protein regulator of cytokinesis 1 4.0
Prim1 Primase, polypeptide 1, 49kDa 3.7
Pttg1 Pituitary tumor-transforming 1 2.4
Racgap1 Rac GTPase activating protein 1 2.1
Rad51ap1 RAD51 associated protein 1 2.7
Shcbp1 SHC SH2-domain binding protein 1 2.9
Spag5 Sperm associated antigen 5 2.8
Spbc24 Spindle pole body component 24 homolog (S. cerevisiae) 2.5
Tk1 Thymidine kinase 1, soluble 3.3
Top2a Topoisomerase (DNA) II alpha 170kDa 2.8
Tpx2 TPX2, microtubule-associated, homolog (Xenopus laevis) 2.8
Trip13 Thyroid hormone receptor interactor 13 2.3
Ttk TTK protein kinase 2.5
Tyms Thymidylate synthetase 3.5
B. Genes down-regulated in both human breast CAFs and Cav-1−/− MSFs (8 genes)
Symbol Gene name Fold-down-regulation in Cav-1 KO
Casp1 Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) −4.2
Dscr1l1 Down syndrome critical region gene 1-like 1 −3.2
Kctd12 Potassium channel tetramerisation domain containing 12 −2.1
Mid1 Midline 1 (Opitz/BBB syndrome) −2.3
Rspo3 R-spondin 3 homolog (Xenopus laevis) −2.3
Stmn2 Stathmin-like 2 −2.2
Tnxb Tenascin XB −3.2
Zfp36l2 Zinc finger protein 36, C3H type-like 2 −2.1