Table 5.

Transcriptional Comparison of Cav-1^−/− MSFs with CAFs Isolated from Individual Patients

Genes up-regulated in Cav-1−/− MSFs and CAFs, either from patient 1, 2, or 3 (178 genes)

ANLN, AP1S3, ASF1B, ASPM, ATAD2, AURKA, AURKB, BIRC5, BLM, BNC1, BRCA1, BRRN1, BUB1, BUB1B, CALD1, CASC5, CASP1, CBX5, CCNA2, CCNB1, CCNB2, CCNE2, CCNF, CDC20, CDC25C, CDC45L, CDC6, CDC7, CDCA1, CDCA2, CDCA3, CDCA5, CDCA7, CDCA8, CDKN3, CENPA, CENPE, CENPF CENPH, CENPI, CENPK, CENPQ, CEP55, CHEK1, CHTF18, CIT, CKAP2L, CKS1B, CKS2, CSRP1, CTH, DEPDC1B, DHFR, DLG7, DSCR1L1, E2F7, ECT2, ESPL1, EXO1, EZH2, FABP5, FANCA, FANCB, FBXO5, FEN1, FIGNL1, FOXM1, FST, GADD45B, GMNN, GRB10, GSG2, H2AFX, HBEGF, HELLS, HMGB1, HMGB2, HMGB3, HMGN2, HMMR, HN1, IDH2, IL11, IQGAP3, ITGA5, KCTD12, KIF11, KIF20A, KIF22, KIF23, KIF2C, KIFC1, KNTC1, KNTC2, KRT19, LIG1, LMNB1, LSM5, LUZP5, MAD2L1, MASTL, MCM10, MCM3, MCM5, MCM6, MCM7, MCM8, MELK, MID1, MKI67, MLF1, MPHOSPH1, MYBL2, NASP, NEK2, NPR3, NUSAP1, OIP5, PBK, PCNA, PDLIM5, PHF20, PLK1, PLK4, POLD1, POLE, PPIL5, PRC1, PRIM1, PRR11, PTK2, PTTG1, RACGAP1, RAD18, RAD51, RAD51AP1, RECQL4, RFC5, RRM1, RSPO3, SDPR, SGOL1, SHCBP1, SLC7A5, SMC2, SMC4, SMTN, SNRPA1, SORBS1, SPAG5, SPBC24, STIL, STMN2, TACC3, TAGLN2, TBC1D1, TGFB2, TGM2, THY1, TK1, TLN1, TNXB, TOP2A, TPM1, TPM2, TPX2, TRIP13, TRPV2, TTK, TYMS, UBE2C, UBE2S, UHRF1, VRK1, WDHD1, WHSC1, ZFP36L2, ZWILCH

Genes down-regulated in Cav-1−/− MSFs and CAFs, either from patient 1, 2, or 3 (127 genes)

ABAT, ABHD4, AGT, ALDH1A1, ALDH2, AMPD3, ANK3, AOX1, AQP1, ARHGDIB, ASPA, ASPN, C1S, C3, CAMK1D, CASP1, CASP4, CCL11, CCL2, CD55, CDH13, CDK6, CH25H, CLEC14A, CNNM2, CST6, CTSH, CTSK, DCAMKL1, DOCK4, DPT, DSCR1, DSCR1L1, DSP, EDNRB, EFEMP1, ELTD1, ENPP2, FIP1L1, FLRT2, GAS1, GCH1, GCLC, GPNMB, GPR116, GPR137B, GPR64, GRIA3, HGF, HIST1H3D, HTR2B, ICAM1, IFIT3, IGF2BP3, IL1RL1, IQGAP2, ITGBL1, ITPR2, JAM2, KCTD12, KLHL13, KLHL24, LMO7, LRP11, LSS, MAF, MAGI2, MARK1, MASP1, MGAM, MGST1, MID1, MITF, MOXD1, NGEF, NMNAT2, NOTCH3, NQO1, NRP2, OLR1, PAPPA2, PCMTD1, PLAT, PLSCR4, PLTP, PLXDC1, PPAP2B, PPFIBP2, PRELP, PRG4, PRICKLE2, PRL, PROS1, PRSS35, PTGIR, PTN, PYCARD, RAB3GAP2, RECK, RGL1, RGS5, RRAGD, RSPO3, SEMA3C, SEPP1, SESN3, SFRP2, SFRP4, SLC15A3, SLC39A8, SLC7A11, SMPDL3A, SNED1, SOCS2, SOD3, SORBS2, STMN2, SULF2, TAC1, TEK, TNFAIP2, TNXB, TOB1, TPP1, VIT, ZFP36L1, ZFP36L2

Inclusion of a transcript from the Cav-1^−/− MSF gene profile in any one of the three patients constituted a hit.