Figure 4.

Selective neuronal cell loss in the CA1 region of the hippocampus in MYC-On mice. A and C: H&E staining and Nissl staining with cresyl violet show a significant level of neurodegeneration in the CA1 region in MYC-On mice. The characteristics of cell death, including condensation of chromatin, pyknotic appearance, and eosinophilic cytoplasm (arrows) are significant in the CA1 region in MYC-On mice (A) whereas no such change is observed in MYC-Off mice (B). Nissl staining clearly demonstrates the selective neurodegeneration in the CA1 region in MYC-On mice (arrowheads, C) but not in MYC-Off mice (D). Scale bars = 100 μm.