Figure 6.

Working memory function is decreased in MYC-On mice (n = 8). Mice were placed in the start arm for 60 seconds before the gate was opened. Once the subject entered an arm the door was closed and the animal was confined for 30 seconds; thereafter it was returned to the start arm for a new trial. A: MYC-On mice had significantly more trouble remembering the arm that they had previously visited and re-entering it (*P < 0.002). B: The time elapse was measured from when the door in the start box was opened until the animal entered the chosen arm. MYC-On mice took significantly less time to enter the chosen arm indicating lack of cognitive flexibility (*P < 0.05). Mean percentage of alternations over six trials.