Figure 7.

Humoral and cell-mediated immune responses to V and V10 in Brown Norway rat reveals complexity in antibody-mediated neutralization of plague. A: LcrV peptide epitope mapping of V and V10 immune sera shows different epitope binding profiles elicited by the two antigens. B: Competition for binding LcrV between neutralizing LcrV monoclonal antibody BA-5 and V or V10 rat immune sera. C: Memory T-cell assay in splenocytes purified from rats immunized with V or V10 shows greater IFN-γ production in V-immunized rats compared with V10-immunized rats.