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A and B: The activity of canonical WNT signaling was increased in grade I chondrosarcomas compared with enchondromas. However on further increase in histological grade, the activity decreased again (Pearson χ2, P = 0.038). C and D: PAI-1 expression, indicating active TGF-β signaling, was found in the majority of central chondrosarcomas. PAI-1 expression was correlated to histological grade (χ2 test, P = 0.002). Original magnifications, ×40.
