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. 2009 Mar;174(3):989–998. doi: 10.2353/ajpath.2009.080422

Figure 5.

Figure 5

A: Presence of antibodies against myosin in EAM mice. Western blot analyses revealed antibodies against myosin in all 25 EAM mice analyzed (3 representative samples are shown lanes 1–3), whereas they were not observed in 19 control mice immunized with PBS in CFA (3 representative samples are shown lanes 4–6). On the left side molecular weights in kDa are represented. B: Immunofluorescent staining on HEp-2 cells to detect autoantibodies from the sera (1:80 dilution) of EAM and (C) Treg depleted EAM mice. The latter shows a cytoplasmic pattern condensed around the nucleus, which diminishes toward the periphery.