Table 1.
Morphometry of Foam Cell and Hemorrhage-Associated Macrophage Subsets
| Measurement | Distance to lipid core (μm) M ± SE (Range) | Distance to neovessels (μm) M ± SE (Range) | Distance to hemorrhage (μm) M ± SE (Range) | Iron score (0–3 scale) M ± SE (Range) | HO-1 intensity (arbitrary density units) M ± SE | 8-oxo-G intensity (arbitrary density units) M ± SE | IL-10 intensity (arbitrary density units) M ± SE |
|---|---|---|---|---|---|---|---|
| Subset | |||||||
| HA-mac | 439 ± 14 | 15.7 ± 5.7 | 3.88 ± 1.8 | 2.25 ± 0.47 | 22.2 ± 3.9 | 14.0 ± 0.96 | 12.3 ± 1.5 |
| (CD163high HLADRlow) | (0 to 1000)** | (10 to 50)*** | (0 to10)** | (1+ to 3+)* | *** | ** | **** |
| FC-mac | 29 ± 15.5 | 785 ± 214 | 150 ± 86 | 0 ± 0 (0 to 0) | 7.95 ± 1.03 | 35.8 ± 4.7 | 4.2 ± 0.4 |
| (CD163low HLADRhigh) | (1 to 100) | (500 to 2000) | (50 to 750) |
*
P < 0.05, Mann-Whitney.
**
P < 0.01, Mann-Whitney.
***
P < 0.005, Mann-Whitney.
****
P < 0.001, Mann-Whitney.
Morphometric comparisons of the two macrophage subsets. Rows, data gathered in the same way (see Materials and Methods) for HA-mac (CD163highHLA-DRlow) and FC-mac (CD163lowHLA-DRhigh). Columns, measurement of respectively: nearest distance to lipid core, nearest distance to microvessels, nearest distance to hemorrhage, cellular iron (where Figure 2D = 3+), HO-1 staining intensity, 8-oxo-G staining intensity.