Figure 2.
The length of homogeneous A-tail affects Alu retrotransposition efficiency. The retrotransposition activity of Alu elements with homogenous A-tail of different lengths driven by the endogenous ORF2p present in HeLa cells was evaluated. Columns represent the mean G418R colonies (n = 3) normalized relative to the Alu with 30 homogenous As that was arbitrarily designated as 100% with the standard deviation shown as error bars. Results significantly different from the A30 control with P-values ≤ 0.0001 (Students paired t-test) are indicated by an asterisk (*).