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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Mol Biochem Parasitol. 2008 Nov 27;164(1):32–44. doi: 10.1016/j.molbiopara.2008.11.005

Table 3.

Hypothetical biological/molecular functions of identified larval proteins released during in vitro transformation of Schistosoma mansoni miracidia to primary sporocysts at 24 hr of cultivation in snail saline (CBSS). S, putative secretory protein; N, putative nonsecretory protein.

Protease/protein degradation/inhibition
Calpain 4, 6, 7 Smp_157500 S endopeptidase, cys-type; Ca-dependent
Alpha-2-macroglobulin related Smp_089670 S endopeptidase inhibitor
DJ-1/PfpI family protein Smp_082030 S serine-type peptidase (S51 family)
Ubiquitin (ribosomal L40e family domain) Smp_089430 S ubiquitin-proteosome protease complex
Dipeptidylpeptidase III Smp_019010 N exopeptidase; cytoplasmic
Cystatin B, putative Smp_006390 N cysteine protease inhibitor
Proteosome subunit (β-type); Smp_025800 N ubiquitin-proteosome protease complex
Proteosome subunit (β-type) Smp_034490 N ubiquitin-proteosome protease complex
Proteosome subunit (alpha-type) Smp_067890 N ubiquitin-proteosome protease complex
Proteosome subunit (alpha-type) Smp_070930 N ubiquitin-proteosome protease complex
Leishmanolysin-like protease Smp_167070 N metalloendopeptidase; M8 family
Protein folding/stress/chaperone
Major egg antigen (p40) (HSP20) Smp_049230/50 S heat-shock protein; alpha-crystallin-like
Major egg antigen (HSPβ1; HSP27) Smp_049240 S heat-shock protein; stress response; chaparone
HSP70 Smp_049550 S heat-shock protein; stress response; chaparone
Immunophilin (FKBP12 binding) Smp_079230 S peptidyl-prolyl cis-trans isomerase; protein folding
Leucine-rich transmembrane protein Smp_147470 S protein-protein interaction; adhesion
Egg protein C122-like Smp_032670.2 S R-spondin-like; stress response
Cyclophilin (CS-A binding) Smp_040130 N peptidyl-prolyl cis-trans isomerase; protein folding
Major surface antigen (HSP70 homologue) Smp_106930 N ATP-binding; stress response; chaparone
HSP90 (83 kDa HSP) Smp_072330 N ATP-binding; stress response; chaparone
HSP70-related Smp_069130.1 N ATP-binding; stress; DnaK family protein
Redox/anti-oxidant/electron transport
Glutathione-S-transferase omega Smp_152710.1 S redox; anti-oxidant
Glutathione-S-transferase 26 kDa Smp_163610 S redox; anti-oxidant; xenobiotic metabolism
Copper/zinc superoxide dismutase, putative Smp_176200.1/2 S redox; anti-oxidant
Thioredoxin peroxidase/peroxiredoxin Smp_158110.1/2 S redox; anti-oxidant
Protein inhibitor of NOS (PIN); dynein lg chain Smp_040680 S microtubule; motor activity; anti-oxidant
Heme binding protein 2-related Smp_016730 S heme binding; anti-oxidant
Peptidyl-gly α-amidating monooxygenase Smp_010820 S redox; protein metabolism
Thioredoxin Smp_008070 N redox; anti-oxidant
Peptidyl-gly α-hydroxylating monooxygenase Smp_145300 N redox; protein metabolism
Malate dehydrogenase, NAD-dependent Smp_047370 N redox; glycolysis
Glycerol 3-phosphate dehydrogenase Smp_030500.1 N redox; CHO metabolism
Carbonyl reductase (short-chain dehydrogenase) Smp_033540 N redox; antioxidant
Glutathione-S-transferase 26 kDa Smp_102070 N redox; anti-oxidant; xenobiotic metabolism
Glutathione-S-transferase 28 kDa Smp_054160 N redox; anti-oxidant; xenobiotic metabolism
Hydroxyacylglutathione hydrolase Smp_091010 N redox; detoxication; xenobiotic metabolism
Cytochrome c Smp_033400 N redox; electron transport
Cytosolic malate dehydrogenase Smp_035270.2 N redox; glycolysis
Glyceraldehyde-3-phosph. dehydrogenase Smp_056970.1 N redox; glycolysis
Microtubule/motility
20.7 kDa tegumental protein; dynein light chain Smp_077310 S microtubule; motor activity; EF-hand domain
Protein inhibitor of NOS (PIN); dynein lg chain Smp_040680 S microtubule; motor activity; anti-oxidant
WD-repeat protein Smp_073940 S actin-binding, putative
β-tubulin Smp_030730 N microtubule; motor activity; GTP-binding
22.6 kDa antigen; dynein light chain Smp_086470 N microtubule; motor activity; EF-hand domain
α-tubulin Smp_016780 N microtubule; motor activity; GTP-binding
Actin-1 Smp_046590.2 N cytoskeletal protein; motility; ATP-binding
Carbohydrate (CHO) metabolism
α-galactosidase/α-N-acetylgalactominidase Smp_179250 S carbohydrase; CHO binding
Endoglycoceramidase Smp_120050 S glycosidase; CHO binding
Egg protein C122-like Smp_032670.2 S heparin-binding, putative
Glucose-6-phosphate isomerase Smp_022400 N CHO metabolism; glycolysis; gluconeogenesis
Eukaryotic phosphomannomutase Smp_087860 N hexose metabolism; mannose biosynthesis
Triosephosphate isomerase Smp_003990 N CHO metabolism; glycolytic activity
Transketolase Smp_059790.2 N CHO metabolism; glycolysis; pentose-P shunt
α-N-acetylgalactosaminidase Sm06626 N carbohydrase activity; CHO binding
Glycogen phosphorylase Smp_143840 N glucose phosphorylation; Glc-1-P synthesis
Phosphoenolpyruvate carboxykinase (PepCK) Smp_005880 N CHO metabolism; gluconeogenesis; GTP binding
Fructose-bisphosphate aldolase class I Smp_042160.2 N CHO metabolism; glycolysis
Transaldolase Smp_070600 N CHO metabolism; glycolysis-pentose-P shunt
Lactate dehydrogenase Smp_038950 N CHO metabolism; glycolysis
Phosphopyruvate hydratase (enolase) Smp_024110 N CHO metabolism; glycolysis
Phosphoglycerate mutase Smp_096760 N CHO metabolism; glycolysis
Malate dehydrogenase (cytosolic) Smp_035270.2 N CHO metabolism; glycolysis; TCA cycle
Glyceraldehyde-3-phosphate dehydrogenase Smp_056790.1 N CHO metabolism; glycolysis
Kinases/phosphorylases
Adenylate kinase Smp_071390 S phosphotransferase; ATP binding
ATP:guanidine kinase smc74 Smp_194770 N creatine kinase-like phosphotransferase
Nucleotide diphosphate kinase Smp_092750 N NTP biosynthesis (CTP, GTP, UTP)
Guanylate kinase (mannosidase, endo-a iso.1) Smp_016880 N Nucleotide binding; GMP cycling; cGMP synth.
Uridine phosphorylase Smp_082420 N glycosyltransferase; uridine binding
Methylthioadenosine phosphorylase-related Smp_171620 N transferase; purine metabolism
Purine nucleoside phosphorylase Smp_090520 N phosphorylase family 2
Protein kinase Smp_152330 N cAMP-dependent; catalytic subunit
Myotonic dystrophy s/t kinase-related Smp_151140 N Serine-threonine kinase
Phosphoenolpyruvate carboxykinase (PepCK) Smp_005880 N CHO metabolism; gluconeogenesis; GTP binding
Glycogen phosphorylase Smp_143840 N CHO metabolism; Glu-1-phosphate synthesis
Phosphoglycerate kinase Smp_018890 N CHO metabolism; glycolysis
Ion-binding proteins
20.7 kDa tegumental protein (dynein light chain) Smp_077310 S Ca-binding; EF-hand domain; motor activity
Annexin Smp_164100 S Ca-binding; EF-hand dom.; phospholipid-binding
Calmodulin Smp_026560.1 S Ca-binding; EF-hand dom.; regulation
Calpain 4, 6, 7 Smp_157500 S Ca-dependent protease
Program cell death protein (sorcin-related) Smp_136640 S Ca-binding; EF-hand dom.; regulation
Superoxide dismutase, putative Smp_176200.1/2 S Cu/Zn-binding; dismutase activity; anti-oxidant
Heme binding protein 2-related Smp_016730 S Fe-heme binding; transport; storage
Ferritin 1 light chain Smp_047650 S Fe-binding; cellular iron transport; storage
Voltage-gated potassium channel Smp_136440 S K-binding; ion channel; K transport
Ferritin light chain Smp_087760 N Fe-binding; cellular iron transport; storage
22.6 kDa antigen (dynein light chain) Smp_086470 N Ca-binding; EF-hand dom.; motor activity
16 kDa egg antigen (SME16) Smp_096390.2 N Ca-binding protein; EF-hand dom.
Myoglobin 1-related Smp_162360 N Fe-heme binding protein; oxygen transport
Venom allergen-like proteins
Venom allergen-like 2 (SmVAL2) Smp_002630 S Sperm-coating protein (SCP)/TAPS domain family
Venom allergen-like 3/23 (SmVAL 3/23) Sm00763 S SCP-TAPS domain; cyst-rich proteinase inhibitor
Venom allergen-like 9 (SmVAL 9) Smp_176180 S SCP-TAPS domain family
Venom allergen-like 15 (SmVAL15) Smp_070250 S SCP-TAPS domain family
Venom allergen-like 26/28 (SmVAL26/28) Smp_154260 S SCP-TAPS domain family
Venom allergen-like 27 (SmVAL27) Smp_154290 S SCP-TAPS domain family
Venom allergen-like 5/15 (SmVAL 5/15) Smp_120670 N SCP-TAPS domain; CRISP-like subfam. glioma