Table 1.
Area under the curve for plasma insulin, glucose, and lactate concentrations over a 1-h infusion of A1 receptor antagonist (DPCPX), A2A receptor blocker (ZM-241385), ADO, or vehicle in normoxic fetal sheep
| Insulin | Glucose | Lactate | |
|---|---|---|---|
| Endogenous ADO | |||
| DPCPX (6) | 72.5±2.8 | 67.8±2.5 | 71.5±4.3 |
| Vehicle (6) | 65.3±4.0 | 60.9±2.3 | 64.9±2.9 |
| P value | 0.06 | 0.03 | 0.21 |
| ZM-241385 (6) | 66.7±5.2 | 62.6±5.9 | 59.7±4.2 |
| Vehicle (6) | 65.8±4.3 | 58.6±1.1 | 58.0±0.7 |
| P value | 0.57 | 0.41 | 0.60 |
| Exogenous ADO | |||
| ADO (9) | 43.8±1.8 | 70.8±2.4 | 89.8±8.6 |
| Vehicle (9) | 63.9±2.8 | 61.5±0.9 | 61.1±0.8 |
| P value | 0.00002 | 0.000001 | 0.0005 |
| ADO + DPCPX (6) | 48.7±1.9 | 72.1±3.0 | 97.1±16.1 |
| ADO + Vehicle (6) | 54.0±4.8 | 63.9±1.5 | 70.0±2.6 |
| P value | 0.31 | 0.05 | 0.04 |
| ADO+ZM-241385 (5) | 67.1±7.4 | 60.6±3.9 | 64.5±5.2 |
| ADO + Vehicle (5) | 50.6±7.0 | 68.8±2.8 | 92.4±13.9 |
| P value | 0.12 | 0.04 | 0.05 |
Number in parentheses represents the number of fetuses. ADO, adenosine. Area under the curve is presented as concentration ratio·min.