Table 1.
Mean blood glucose and percent blood glucose above baseline range for marmosets treated with high, moderate, and low doses of STZ
| Cumulative Dose, mg/m2 | Treatment Course | Blood Glucose, mg/dl | Values Above Normal Blood Glucose Range, n (%) | |
|---|---|---|---|---|
| Baseline | 0 | 194.44 (47.41) | 4 of 20 (20.0%) | |
| Low-dose STZ | 1,440 | 90 mg/kg on days 0 and 21 | 272.10 (86.24) | 28 of 50 (56.0%) |
| Marmoset A | 303.28 (99.41) | 17 of 25 (68.0%) | ||
| Marmoset B | 240.92 (57.26) | 11 of 25 (44.0%) | ||
| Moderate-dose STZ | 2,280 | 90 mg/kg on days 0 and 14; 100 mg/kg on days 28 and 63 | 143.00 (42.08) | 8 of 62 (12.9%) |
| Marmoset C | 134.73 (38.66) | 2 of 31 (6.4%) | ||
| Marmoset D | 152.18 (44.50) | 6 of 31 (19.4%) | ||
| High-dose STZ | 3,000 | Above doses+120 mg/kg on day 105 | 360.63 (135.06) | 35 of 44 (79.5%) |
| Marmoset C | 300.81 (125.82) | 14 of 22 (63.6%) | ||
| Marmoset D | 434.53 (109.08) | 21 of 22 (95.4%) |
Values were calculated over the course of treatment as follows: for low-dose streptozotocin (STZ) beginning on day 2, for moderate-dose STZ from day 2 to day 105, and for high-dose STZ beginning on day 107. Blood glucose values are means (SD). Baseline blood glucose range =147.03-241.85 mg/dl.