Fig. 2.

Experiment 1: male DIO rats were weaned onto HE diet and randomized into 3 groups as in Fig. 1. A: at 3 wk, rats received 5 mg/kg ip leptin, and food intake was monitored at 4 and 24 h and compared with their saline-injected intake. B: average change in baseline core temperature 0–4 h and 12–24 h following leptin administration at 3 wk. C: cumulative activity measured in arbitrary units from intraperitoneal telemetry probe during the 4 h following saline or leptin administration at 3 wk. Data are means ± SE. *P ≤ 0.05 when food intake following leptin treatment was significantly reduced compared with food intake following saline administration.