Fig. 4.

Experiment 1: male DIO rats were weaned onto HE diet and randomized into 3 groups as in Fig. 1. At 7 (A) and 13 wk (B), rats received 5 mg/kg ip leptin, and food intake was monitored at 4 and 24 h and compared with their saline-injected intake. Cumulative activity measured in arbitrary units from intraperitoneal telemetry probe during the 4 h following saline or leptin administration at 7 (C) and 13 wk (D). Data are means ± SE. *P ≤ 0.05 when food intake following leptin treatment was significantly reduced compared with food intake following saline administration. Data represent rats from Table 1.