Table 1.

Experiment 1

	Sed	Ex	Ex/Sed
Weeks 0–3
Initial body weight, g	73±4	63±6
Body weight week 3, g	206±6a	166±7b
Body weight gain weeks 1–3, g	133±4a	103±3b
3-wk 24-h food intake, g	22±1.4	19±1
3-wk glucose, mg/dl	118±3.7a	97±2.9b
3-wk leptin, ng/ml	3.34±0.3	2.36±0.3
3-wk insulin, ng/ml	1.79±0.2a	0.51±0.2b
Weeks 3–7
Body weight week 7, g	401±10a	319±12b	341±11b
Body weight gain weeks 1–7, g	328±8a	255±9b	279±8b
Body weight gain weeks 3–7, g	195±7a	152±9b	175±6ab
7-wk 24-h food intake, g	26±0.6	23±0.5	27±1.1
7-wk glucose, mg/dl	120±7.0a	108±6.8b	120±3.1a
7-wk leptin, ng/ml	9.6±1.8a	3.7±0.4b	6.3±0.3ab
7-wk insulin, ng/ml	1.0±0.3	0.8±0.3	1.0±0.3
Weeks 3–13
Final body weight, g	556±11a	447±12b	498±16c
Body weight gain weeks 1–13, g	484±9a	383±7b	436±13c
Body weight gain weeks 3–13, g	351±9a	280±5b	332±12a
13 wk 24 h food intake, g	24±1.1	24±0.8	23±0.8
Total fat pads, g	44.8±3.0a	14.3±0.7b	24.3±1.7c
Total fat pads/body weight, %	8.02±0.42a	3.32±0.2b	4.94±0.24c
13-wk glucose, mg/dl	107±5.8	111±7.9	107±8.1
Final leptin, ng/ml	8.0±0.8	10.1±1.7	7.0±0.7
Final insulin, ng/ml	0.8±0.1	0.4±0.1	0.5±0.1

Values are means ± SE. Sedentary (Sed) rats were left sedentary for 13 wk (Sed; n = 6). Exercised (Ex) rats had free access to a running wheel for 13 wk (Ex; n = 6). Following 3 wk, one-half of the Ex rats had their running wheels removed and were allowed to remain sedentary for 10 wk more (Ex/Sed; n = 6). Rats were evaluated after 3, 7, and 13 wk of experimental manipulation. Total fat pads = sum of epididymal (EPI), retroperitoneal (RP), perirenal (PERI), mesenteric (MES), and inguinal (ING) pads.

^a,b,cParameters with differing superscripts differ from each other at the P < 0.05 level by post hoc Bonferroni adjustment after significant intergroup differences were found by 1-way ANOVA.