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LPS induced septic lethality rates in littermate control and KitW-sh/W-sh mice. Percent survival is plotted for both groups every 12 h following injection of saline or a high dose of LPS (15 mg/kg, at time 0) known to cause lethality. By 72 h postinjection, no WT mice survived compared with 30% survival of KitW-sh/W-sh mice (P < 0.01). There was no further change in survival after 72 h.
