Table 5.
Classification of PR Status of the Discovery and Validation Sets Using the ΔΔCT Cutoff-Point and Clustering Methods
| Discovery (n = 67) |
Validation (n = 321) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ΔΔCTcutoff-point |
Clustering |
ΔΔCTcutoff-point |
Clustering |
|||||||
| Allred TS* | IHC (% of total) | PR+ | PR− | PR+ | PR− | IHC (% of total) | PR+ | PR− | PR+ | PR− |
| 0 | 20 | 1 | 19 | 1 | 19 | 35 | 11 | 24 | 7 | 28 |
| 2 | 0 | 0 | 0 | 0 | 0 | 9 | 1 | 8 | 1 | 8 |
| PR−† | 20 (30%) | 1 | 19 | 1 | 19 | 44 (14%) | 12 | 32 | 8 | 36 |
| 3 | 1 | 0 | 1 | 0 | 1 | 36 | 24 | 12 | 20 | 16 |
| 4 | 3 | 3 | 0 | 2 | 1 | 28 | 26 | 2 | 26 | 2 |
| 5 | 11 | 9 | 2 | 8 | 3 | 51 | 51 | 0 | 50 | 1 |
| 6 | 11 | 11 | 0 | 10 | 1 | 47 | 47 | 0 | 46 | 1 |
| 7 | 7 | 7 | 0 | 7 | 0 | 58 | 59 | 0 | 58 | 0 |
| 8 | 14 | 14 | 0 | 14 | 0 | 57 | 56 | 0 | 57 | 0 |
| PR+‡ | 47 (70%) | 44 | 3 | 41 | 6 | 277 (86%) | 263 | 14 | 257 | 20 |
*
Allred total score.
†
Total number of specimens with Allred TS0 and TS2 in each set.
‡
Total number of specimens with Allred TS3 to TS8 in each set.