Figure 5.

Identification of chromosomal breakpoints interrupting the Fc locus in two cases of follicular lymphoma by dual color FISH with cosmid probes cos34 (FCGR2B) (green signals) and cos2 (FCGR3B) (red signals). Chromosomes are counterstained with 4′,6-diamidino-2-phenylindole. (A) Lymphoma case Az shows hybridization of cos34 to the derivative 1 chromosome and cos2 to the der(22). (B) In case 650, a der(1) breakpoint within cos34 was detected. Cos 34 showed signals on the der(1), der(22), and normal 1 whereas cos 2 gave signals on the der(22) and normal 1 only.