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. Author manuscript; available in PMC: 2010 Apr 9.
Published in final edited form as: J Med Chem. 2009 Apr 9;52(7):1853–1863. doi: 10.1021/jm801317h

Table 2.

CDK-2/CyclinE Inhibition by Substituted Maleimides.[a]

Compound IC50 (nM)
CDK-2/cyclinE		 IC50 Ratio
CDK-2/cyclinE
GSK-3β
Staurosporine 3.8 0.8
1 1410 40
2 237 670
7 11700 12300
11 99000 410
14 1160 150
15 337 660
19 1840 2.6
21 1070 30
24 32000 130
31 149 27
32 27 5
33 3880 32300
[a]

These compounds were tested at Reaction Biology, Inc. (http://www.reactionbiology.com).