Table 2.
Variable | Overall | Lagging (≤25%) | 25–50% | 50–75% | Leading (>75%) | P-value |
---|---|---|---|---|---|---|
N=81,374 (100%) | n=12,226 (15.0%) | n=18,201 (22.4%) | n=26,123 (32.1%) | n=24,824 (30.5%) | ||
Demographics | ||||||
Age, ya | 68 (56, 79) | 71 (58, 81) | 69 (58, 80) | 68 (56, 78) | 67 (56, 78) | <0.0001 |
Men | 60.1 | 55.9 | 60.0 | 60.6 | 61.7 | <0.0001 |
African-American | 10.8 | 13.6 | 8.8 | 12.1 | 9.4 | <0.0001 |
Past Medical History | ||||||
Hypertension | 71.3 | 71.9 | 71.8 | 72.0 | 70.0 | <0.0001 |
Diabetes mellitus | 33.3 | 36.0 | 33.3 | 33.8 | 31.3 | <0.0001 |
Hyperlipidemia | 51.8 | 43.5 | 50.2 | 54.2 | 54.6 | <0.0001 |
Current/recent smoking | 27.2 | 24.2 | 25.3 | 28.2 | 29.0 | <0.0001 |
Prior MI | 29.2 | 27.3 | 26.3 | 31.6 | 29.8 | <0.0001 |
Prior heart failure | 17.9 | 21.4 | 18.5 | 17.8 | 15.8 | <0.0001 |
Prior PCI | 21.4 | 19.2 | 20.9 | 22.2 | 22.1 | <0.0001 |
Prior CABG | 19.5 | 19.6 | 19.7 | 19.7 | 19.2 | 0.3 |
Prior stroke | 10.4 | 11.7 | 10.2 | 10.7 | 9.6 | <0.0001 |
Presenting Features | ||||||
+ Cardiac markers | 91.4 | 84.4 | 90.8 | 93.4 | 93.3 | <0.0001 |
ST depression | 30.6 | 28.8 | 31.6 | 30.5 | 30.9 | <0.0001 |
Signs of heart failure | 24.3 | 25.9 | 26.2 | 23.5 | 23.1 | <0.0001 |
Heart rate (bpm)a | 83 (70, 99) | 85 (72, 101) | 83 (70, 100) | 83 (70, 98) | 82 (70, 97) | <0.0001 |
Systolic BP (mm Hg)a | 144 (123, 165) | 143 (122, 164) | 142 (122, 163) | 144 (124, 165) | 145 (125, 166) | <0.0001 |
SCr (mg/dL)b | 1.39 (1.53) | 1.51 (1.62) | 1.43 (2.00) | 1.38 (1.43) | 1.32 (1.16) | <0.0001 |
eGFR (mL/min/1.73m)2c | 65.7 (47.0, 83.7) | 62.3 (42.1, 81.2) | 65.0 (45.9, 83.5) | 66.7 (48.2, 84.3) | 67.2 (49.8, 84.1) | <0.0001 |
CCr (mL/min)a,d | 53.2 (34.1, 75.6) | 47.1 (29.5, 69.8) | 51.6 (33.0, 75.0) | 54.3 (34.9, 76.4) | 56.2 (36.9, 77.6) | <0.0001 |
Primary Attending | ||||||
Care by cardiologist | 59.0 | 45.3 | 58.0 | 59.6 | 65.9 | <0.0001 |
Abbreviations: BP, blood pressure; CABG, coronary artery bypass grafting; CCr, creatinine clearance; eGFR, estimated glomerular filtration rate; HF, heart failure; MI, myocardial infarction; PCI, percutaneous coronary intervention; SCr, serum creatinine.
Data are expressed as percentages except for continuous variables
Expressed as medians (25th, 75th percentile)
Expressed as mean (SD)
Conversion factors: serum creatinine in mg/dL to mmol/L, x88.4; eGFR in mL/min/1.73 m^2 to mL/s/1.73 m^2, x0.01667.
Determined by using MDRD Study equation.
Determined with Cockcroft-Gault formula.