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. Author manuscript; available in PMC: 2010 Mar 18.
Published in final edited form as: FEBS Lett. 2009 Feb 21;583(6):1023–1028. doi: 10.1016/j.febslet.2009.02.027

Table 2.

Disease relevance of genes regulated by Tie-1 expression in HUVECs. Genes identified in Table 1 were analyzed by the Ingenuity Pathway Analysis Program using the Ingenuity Knowledge Base as the reference set. Of the 91 input genes (including Tie-1), 70 were eligible for functional analysis, and 59 were identified to have functions/diseases relevance. The top 10 functions are presented here. Detailed explanation of the method used to calculate p-values can be obtained from Ingenuity’s Website (https://analysis.ingenuity.com/pa/info/help/help.htm).

Function Annotation P-value Molecules # Molecules (of 59)
Connective tissue disorder 6.80E-14 ALOX5, BDNF, C1R, CCL8, CCL23, CFB, CLEC4E, COL3A1, CSF2, CSF3, CTSS, CXCL2, CXCL3, CXCL5, CXCL6, G0S2, IL1B, IL7R, RCSD1, SLC26A2, SOD2, TLR2, TNFAIP6, TNFRSF9 24
Rheumatic disease 5.45E-13 ALOX5, BDNF, C1R, CCL8, CCL23, CFB, CLEC4E, CSF2, CSF3, CTSS, CXCL2, CXCL3, CXCL5, CXCL6, G0S2, IL1B, IL7R, RCSD1 SOD2, TLR2, TNFAIP6, TNFRSF9 22
Arthritis 7.19E-13 ALOX5, BDNF, C1R, CCL8, CCL23, CFB, CLEC4E, CSF2, CSF3, CTSS, CXCL2, CXCL3, CXCL5, CXCL6, G0S2, IL1B, IL7R, RCSD1, SOD2, TLR2, TNFAIP6 21
Autoimmune disease 3.16E-12 ALOX5, C1R, C1S, CCL8, CCL23, CFB, CLEC4E, CSF2, CSF3, CXCL2, CXCL3, CXCL5, CXCL6, G0S2, IL1B, IL7R, KIT, RCSD1, TLR2, TNFAIP6, TNFRSF9 21
Rheumatoid arthritis 7.35E-12 ALOX5, C1R, CCL8, CCL23, CFB, CLEC4E, CSF2, CXCL2, CXCL3, CXCL5, CXCL6, G0S2, IL1B, IL7R, RCSD1, TLR2, TNFAIP6 17
Skeletal and muscular disorder 1.31E-11 ALOX5, BDNF, C1R, CCL8, CCL23, CFB, CLEC4E, COL3A1, CSF2, CSF3, CTSS, CXCL2, CXCL3, CXCL5, CXCL6, G0S2, IL1B, IL7R, RCSD1, SLC26A2, SOD2, TLR2, TNFAIP6, TNFRSF9 24
Immunological disorder 6.58E-11 ALOX5, BDNF, C1R, C1S, CCL8, CCL23, CFB, CLEC4E, CSF2, CSF3, CTSS, CXCL2, CXCL3, CXCL5, CXCL6, G0S2, IL1B, IL7R, KIT, RCSD1, TLR2, TNFAIP6, TNFRSF9 23
Inflammatory disorder 1.78E-10 ALOX5, BDNF, C1R, CCL8, CCL23, CFB, CLEC4E, CSF2, CSF3, CTSS, CXCL2, CXCL3, CXCL5, CXCL6, EBI3, G0S2, IL1B, IL7R, KIT, POSTN, RCSD1, SELE, SOD2, TLR2, TNFAIP6, TNFRSF9 26
Inflammatory response 2.44E-10 ALOX5, CCL8, CCL23, CCL3L3, CSF2, CSF3, CXCL2, CXCL3, CXCL5, CXCL6, DARC, IL1B, LCN2, SELE, SERPINA3, TLR2, TNFAIP6 17
Cell movement of phagocytes 1.40E-09 CCL8, CCL23, CFB, CSF2, CSF3, CTSS, CXCL3, CXCL5, CXCL6, IL1B, SELE, SERPINA3, TLR2 13