Skip to main content
. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2008 Nov 5;234(3):361–369. doi: 10.1016/j.taap.2008.10.009

Figure 1. DMBA metabolic pathway.

Figure 1

The parent compound, DMBA, is bioactivated by CYP450 isoform 1B1 (CYP1B1) to a DMBA-3, 4-epoxide intermediate, which is hydrolyzed by mEH to form DMBA-3,4-diol. This compound further undergoes bioactivation by either CYP1B1 or 1A1 to form the ultimate carcinogenic and ovotoxic metabolite, DMBA-3,4-diol-1,2-epoxide (Adapted from Miyata et al., 1999).