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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2008 Nov 5;234(3):361–369. doi: 10.1016/j.taap.2008.10.009

Figure 5. Effect of CHO (mEH inhibitor) on DMBA- or DMBA-3,4-diol-induced follicle loss.

Figure 5

Ovaries from PND4 Fischer 344 rats were cultured with (A) vehicle control or media containing DMBA (1 μM) +/− CHO (2 mM) for 4 days; or (B) vehicle control or media containing DMBA-3,4-diol (75 nM) +/− CHO (2 mM) for 4 days. Following incubation, ovaries were collected, processed for histological evaluation and healthy follicles were counted as described in methods. Values are mean ± SE total follicles counted/ovary, n=5; * = different from control in each follicle type, P < 0.05.