TABLE 2.
Brachial Artery Parameters
CAD (n=13) | Healthy (n=16) | |||||
---|---|---|---|---|---|---|
Placebo | Fasudil | P | Placebo | Fasudil | P | |
Baseline Diameter, mm | 3.5±0.2 | 3.5±0.2 | 0.11 | 3.6±0.2 | 3.6±0.2 | 0.69 |
FMD, % | 9.4±1.9 | 13.4±1.9 | 0.001 | 11.3±1.4 | 7.7±1.1 | 0.07 |
TNG mediated dilation, % | 15.6±2.4 | 15.3±2.3 | 0.89 | 14.4±1.7 | 13.9±1.5 | 0.94 |
RH, % (increase) | 616±81 | 489±37 | 0.22 | 651±47 | 756±80 | 0.23 |
TNG hyperemia, % (increase) | 96±5.8 | 92±8.9 | 0.74 | 103 6.5 | 91±5.8 | 0.27 |
Data are presented as mean±SE. FMD indicates flow-mediated dilation; TNG, nitroglycerin; RH, reactive hyperemia.