. Author manuscript; available in PMC: 2010 Apr 1.

Published in final edited form as: Biochim Biophys Acta. 2008 Nov 11;1788(4):768–778. doi: 10.1016/j.bbamem.2008.10.023

Table 3.

Reported effects of the expression of connexins on the structure and/or functions of tight junctions

Connexin	Action	TJ protein	Effects on			Cell types	References
			Protein expression	Barrier function^a	Ouabain effects^b
Cx26	Expression	Claudin-4				Caco-2 cells	[83]
	Expression	Claudin-14			P	Calu-3 cells	[84]
					P		[85]
Cx32	Expression	Occludin, Claudin-1, Claudin-2, MAGI-1				Cx32-deficient hepatocytes	[20]
	Expression	Occludin, Claudin-1, Claudin-2, MAGI-1				Cx32-deficient hepatocytes	[21]
	Expression	Occludin, Claudin-1, ZO-1				Cx32-deficient hepatocytes	[80,85]
	Expression	Occludin, Claudin-1				Cx32-deficient hepatocytes (CHST8 and Cx32KOH)	[126]
	Expression	Occludin, Claudin-1, Claudin-2, MAGI-1				Cx32-deficient hepatocytes	[81]

An increase in the barrier function of tight junctions corresponds to either an increase in transepithelial electrical resistance (TER) or a lowered paracellular flux of a solute.

P: protect disruption of barrier and fence functions of TJs by the Na⁺/K⁺-ATPase inhibitor ouabain.