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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Neurobiol Aging. 2007 Aug 27;30(3):388–393. doi: 10.1016/j.neurobiolaging.2007.07.013

Figure 2.

Figure 2

A: RT-PCR analysis of mRNA from the frontal cortex of the MAPT ΔK280 case and two healthy controls. In the top panel, the bars depict the ratios of the exon 10+ (4R-tau) and exon 10− (3R-tau) transcripts as quantified by intensities of the respective bands (see lower pane). Error bars represent standard error of the mean.

B: Western blot analysis of dephosphorylated, soluble (Lane 1) and sarkosyl-insoluble (Lanes 2) tau from the frozen frontal cortex of the ΔK280 case. Lane 3 shows sarkosyl-insoluble tau from the frontal cortex of another Alzheimer’s disease case, without MAPT mutations. Lanes L are recombinant tau isoforms, as labelled on the left and right edges.