Table 1.

Replication analyses for five SNPs (rs2287498, rs12951053, rs9894946, rs1625895, rs1042522) in the TP53 region in white non-Hispanic serous invasive ovarian cancer cases ^*^†

					All Sites		All sites except Discovery sites

Site	HWE	MAF	N cases	N controls	Posterior Median OR	95% Credible Intervals	Posterior Median OR	(95% Probability Intervals)
*rs2287498*
HAW	0.019	0.076	36	157	1.26	(0.84 – 1.84)	1.19	(0.74 – 1.79)
MALOVA	0.991	0.086	267	1209	1.24	(0.96 – 1.57)	1.21	(0.93 – 1.55)
MAYO	0.480	0.053	193	441	1.42	(1.05 - 1.98)	Omitted
NCOCS	0.973	0.062	391	786	1.41	(1.11 – 1.83)	Omitted
POCS	0.396	0.084	118	618	1.26	(0.91 – 1.70)	Omitted
SEA	0.064	0.072	324	1213	1.16	(0.88 – 1.49)	1.14	(0.86 – 1.49)
STA	0.163	0.069	154	356	1.27	(0.91 – 1.74)	1.22	(0.85 – 1.71)
UKO	0.524	0.072	121	578	1.26	(0.90 – 1.72)	1.21	(0.84 – 1.68)
USC	0.574	0.062	255	569	1.46	(1.12 – 1.98)	1.44	(1.07 – 2.00)
Overall			1,859	5,927	1.30	(1.07 – 1.58)	1.23	(0.94 – 1.58)
Bayes Factor					165.7		16.3
*rs12951053*
AUS	0.332	0.069	443	1060	1.29	(1.03 – 1.62)	1.27	(1.00 – 1.62)
HAW	0.853	0.073	36	157	1.16	(0.79 – 1.63)	1.11	(0.72 – 1.61)
MALOVA	0.148	0.094	156	1018	1.19	(0.92 – 1.64)	1.16	(0.88 – 1.53)
MAYO	0.434	0.066	193	456	1.23	(0.92 - 1.64)	Omitted
NCOCS	0.230	0.061	391	786	1.34	(1.06 – 1.75)	Omitted
NEC	0.030	0.066	287	910	1.21	(0.93 - 1.56)	1.18	(0.90 - 1.55)
NHS	0.094	0.059	60	355	1.05	(0.67 – 1.44)	0.99	(0.59 – 1.40)
POCS	0.236	0.094	118	624	1.16	(0.86 – 1.53)	Omitted
SEA	0.450	0.082	321	1195	1.06	(0.81 – 1.34)	1.03	(0.78 – 1.32)
STA	0.163	0.069	149	356	1.18	(0.86 – 1.60)	1.14	(0.82 – 1.58)
UCI	0.487	0.080	148	458	1.16	(0.86 – 1.54)	1.12	(0.82 – 1.53)
UKO	0.060	0.073	117	563	1.24	(0.92 – 1.66)	1.21	(0.88 – 1.67)
USC	0.614	0.075	255	570	1.22	(0.94 – 1.58)	1.19	(0.91 – 1.58)
Overall			2,585	8,508	1.19	(1.01 – 1.38)	1.14	(0.93 – 1.36)
Bayes Factor					47.8		9.2
*rs9894946*
AUS	0.970	0.164	297	665	0.98	(0.75 – 1.24)	0.93	(0.73 – 1.20)
HAW	0.280	0.170	29	144	0.98	(0.57 – 1.52)	0.89	(0.54 – 1.39)
MAYO	0.009	0.182	189	444	0.96	(0.73 - 1.25)	0.92	(0.70 – 1.20)
POCS	0.053	0.130	117	621	1.41	(1.01 – 2.06)	Omitted
Overall			832	1,874	1.06	(0.74 – 1.55)	0.91	(0.62 – 1.33)
Bayes Factor					1.9		0.4
*rs1625895*
AUS	0.689	0.128	298	666	0.98	(0.76 – 1.23)	0.96	(0.75 – 1.20)
HAW	0.978	0.145	30	145	0.98	(0.65 – 1.39)	0.94	(0.62 – 1.36)
MAL	0.044	0.100	236	873	1.08	(0.84 – 1.38)	1.05	(0.81 – 1.35)
MAY	0.023	0.135	192	455	1.06	(0.83 - 1.37)	1.03	(0.81 – 1.35)
NCOCS	0.906	0.151	331	637	0.96	(0.76 – 1.19)	0.94	(0.75 – 1.17)
POCS	0.975	0.098	117	617	1.23	(0.92 – 1.75)	Omitted
SEA	0.509	0.129	212	834	1.07	(0.83 - 1.37)	1.04	(0.81- 1.34)
STA	0.036	0.136	158	359	1.01	(0.74- 1.34)	0.98	(0.73- 1.30)
Overall			1,574	4,586	1.04	(0.86 - 1.25)	0.99	(0.81 - 1.20)
Bates Factor					2.0		0.8
rs1042522
AUS	0.002	0.239	194	360	0.99	(0.79 – 1.22)	0.97	(0.77 – 1.21)
HAW	0.978	0.145	30	145	1.00	(0.69 – 1.36)	0.97	(0.66 – 1.34)
MAL	0.044	0.100	236	873	1.10	(0.92 – 1.32)	1.09	(0.90 – 1.31)
MAYO	0.057	0.254	192	455	1.14	(0.93 - 1.42)	1.13	(0.91 – 1.41)
NCOCS	0.122	0.263	252	437	1.05	(0.85 – 1.29)	1.04	(0.84 – 1.27)
POCS	0.038	0.240	118	620	1.21	(0.97 – 1.57)	Omitted
SEA	0.796	0.259	212	842	1.04	(0.85 - 1.26)	1.03	(0.83 - 1.25)
STA	0.087	0.247	157	363	1.05	(0.82 - 1.34)	1.03	(0.81 - 1.32)
Overall			926	4,236	1.07	(0.91 - 1.26)	1.03	(0.86 – 1.23)
Bayes Factor					4.0		1.9

Results in bold type have probability intervals that excludes 1.0

^†

Analyses are adjusted for age and prior breast cancer