TABLE 2.

Characteristics of SNPs in associated genes on chromosome 6q

										Allele Frequency
SNP	Location on Chr. 6 (bp)	Gene/SNP Location	No. Genotyped/ Phenotyped	HW P Value	Call Rate	Associated Allele	Ancestral/Derived	Effect Size (%)	Association P Value	Hutt+	CEU	YRI	CHB	JPT
rs7745725	152,944,398	SYNE1 intron 3	333	0.679	1.000	T	D	3.01	1.48 × 10−11	0.650	0.808	0.467	0.778	0.633
rs9384296	155,622,957	TIAM2 intron 16	331	0.567	0.984	G	A	8.72	1.85 × 10−09	0.773	0.842	0.875	0.622	0.656
rs6917698	157,535,466	ARID1B intron 6	350	0.707	0.999	A	A	6.92	2.48 × 10−09	0.886	0.783	0.950	0.756	0.778
rs9364496	159,092,493	SYTL3 intron 5	331	0.223	0.989	G	A	0.11	1.91 × 10−11	0.647	0.742	0.825	0.200	0.159
rs8191829	160,449,889	IGF2R intron 21	349	0.366	0.994	G	A	2.51	3.27 × 10−14	0.611	0.758	0.695	0.656	0.636
rs6919346	160,930,770	LPA intron 37	333	0.476	1.000	G	A	3.84	6.27 × 10−12	0.690	0.825	0.992	0	0
rs1853021	161,055,668	LPA 5′UTR (+93C/T)	364	0.483	0.915	T	D	0.17	1.60 × 10−08	0.111	na	na	na	na
rs14224	161,108,190	PLG exon 7 (C257C)	349	0.352	0.997	C	A	5.83	7.56 × 10−19	0.282	0.433	0.551	0.523	0.489
rs4252125	161,122,651	PLG exon 11 (D472N)	335	0.698	1.000	G	D	1.22	1.55 × 10−11	0.437	0.675	0.875	1	1
rs2022991	162,218,580	PARK2 intron 6	348	0.313	0.993	G	D	5.0	1.13 × 10−22	0.186	0.342	0.325	0.489	0.557
rs11966948	163,610,673	PACRG intron 5	349	0.901	0.999	A	A	2.25	1.06 × 10−08	0.438	0.642	0.450	0.678	0.578

Alleles associated with higher levels of plasma Lp(a) are shown (forward strand). Hutterite allele frequencies and Hardy-Weinberg test statistics were corrected for relatedness among individuals in the sample (41, 42). Allele frequencies in European (CEU), African (YRI), Chinese (CHB), and Japanese (JPT) populations are shown (HapMap). na, not typed in HapMap samples; UTR, untranslated region.