TABLE 3.
Association with Lp(a) |
|||||||
---|---|---|---|---|---|---|---|
SNP | Gene | n | Location on Chromosome 6 (bp) | MAF | Association with Kringle IV Number P Value | P Value | P Value with Covariate |
rs7745725 | SYNE1 | 55 | 152,893,977 | 0.49 | 0.976 | 0.00093 | 0.00064 |
rs9384296 | TIAM2 | 55 | 155,572,536 | 0.27 | 0.990 | 0.78950 | 0.56890 |
rs6917698 | ARID1B | 58 | 157,485,045 | 0.15 | 0.986 | 0.00065 | 0.00057 |
rs9364496 | SYTL3 | 54 | 159,042,072 | 0.45 | 0.740 | 0.00142 | 0.00322 |
rs8191829 | IGF2R | 58 | 160,399,468 | 0.49 | 0.505 | 0.00098 | 0.00164 |
rs6919346 | LPA | 55 | 160,880,349 | 0.24 | 0.784 | 0.00123 | 0.00030 |
rs14224 | PLG | 57 | 161,057,769 | 0.23 | 0.402 | 0.01255 | 0.00944 |
rs2022991 | PARK2 | 58 | 162,168,159 | 0.19 | 0.00054 | 0.00003 | 0.00017 |
P values for associations with Lp(a) are shown without kringle IV number as a covariate and with kringle IV number as a covariate. Samples sizes for the kringle IV studies (n) are shown. Allele frequencies are adjusted for relatedness. MAF, minor allele frequency.