TABLE 4.
Characteristics of the CLEAR case and control samples
| All | Cases | Controls | P Value | |
|---|---|---|---|---|
| n | 1,053 | 493 | 560 | |
| Mean age (range) | 67.0 (31–92) | 70.0 (46–89) | 64.3 (31–92) | 9.60 × 10−25 |
| Mean BMI | 28.4 (4.9) | 27.8 (4.8) | 29 (4.9) | 0.0004 |
| Mean total cholesterol (mg/dl) | 189.2 (37.6) | 182.6 (38.0) | 194.8 (36.3) | 3.23 × 10−08* |
| Mean LDL-cholesterol (mg/dl) | 111.3 (31.7) | 105.6 (31.3) | 116.5 (31.3) | 1.65 × 10−07* |
| Mean LDL-B100 (mg/dl) | 64.7 (18.5) | 60.9 (17.9) | 68.2 (18.3) | 1.42 × 10−09* |
| Mean HDL-cholesterol (mg/dl) | 46.3 (14.6) | 43.3 (12.9) | 48.9 (15.5) | 2.83 × 10−11* |
| Mean APOAI (mg/dl) | 136.5 (25.5) | 130.8 (24.2) | 141.3 (25.8) | 6.14 × 10−12* |
| Mean triglycerides (mg/dl) | 149.0 (108.8) | 157.3 (103.8) | 142.0 (112.6) | 0.0003* |
| Mean VLDL-cholesterol (mg/dl) | 29.5 (20.3) | 31.3 (20.1) | 27.8 (20.3) | 0.0002* |
| Mean Lp(a) (nmole/L)a | 65.2 (86.4) | 89.0 (105.5) | 45.7 (60.0) | 5.00 × 10−10* |
| Percentage on lipid meds | 431 | 312 | 119 | 1.66 × 10−45 |
| Percentage of current smokers | 192 | 139 | 53 | 2.51 × 10−15 |
| Percentage diabetic | 146 | 97 | 49 | 2.23 × 10−07 |
| Percentage on hypertensives | 633 | 406 | 227 | 1.75 × 10−45 |
Means (±SD) are show for each trait. P value for comparison between cases and controls using t-test or χ2 test; *comparison performed on log-transformed values. All are Caucasian males.
a
Approximately equivalent to 5.2 (6.9) mg/dl (All), 7.1 (8.4) mg/dl (Cases), and 3.6 (4.8) mg/dl (Controls).