TABLE 5.

Association studies with plasma Lp(a) levels in the CLEAR cohort

A				Genotype versus Lp(a) Levels		Genotype versus Carotid Artery Disease
Gene	rs Number	MAF	HW P	B	P Value	B	P Value
TIAM2	rs9384296	0.15	0.80	0.164	0.122	0.8597	0.299
ARID1B	rs6917698	0.22	0.22	0.063	0.506	0.9225	0.531
SYTL3	rs9364496	0.25	0.80	0.103	0.237	1.0110	0.926
IGF2R	rs8191829	0.23	0.72	−0.086	0.337	1.2780	0.0438
LPA	rs6919346	0.16	0.40	−0.663	3.83 × 10−11	0.6619	0.0036
PLG	rs14224	0.41	0.21	0.219	0.0036	0.9697	0.767
PARK2	rs2022991	0.33	0.83	−0.026	0.748	0.7488	0.009
B		Genotype versus Isoform Size		Genotype versus Lp(a)		Genotype versus Lp(a) with Covariate (Isoform Size)
Gene	rs Number	B	P Value	B	P Value	B	P Value
TIAM2	rs9384296	1.329	0.213	−0.082	0.797	0.164	0.509
ARID1B	rs6917698	0.248	0.815	−0.238	0.470	−0.180	0.482
SYTL3	rs9364496	−0.183	0.872	0.296	0.399	0.197	0.273
IGF2R	rs8191829	1.514	0.143	−0.335	0.306	−0.151	0.553
LPA	rs6919346	0.959	0.376	−0.981	0.002	−0.877	0.0004
PLG	rs14224	−2.405	0.0045	0.676	0.0097	0.270	0.205
PARK2	rs2022991	1.003	0.276	−0.136	0.635	0.102	0.644

A: Analyses in 1,054 subjects with Lp(a) measurements, including 306 cases (with carotid artery disease) and 534 controls (Table 4). B: Analyses in 99 individuals selected for isoform size studies. Last two columns are analyses adjusted for isoform size. MAF, minor allele frequency; HW P, Hardy-Weinberg P value; B, regression slope coefficient. Significant P values are shown in bold italic.