Fig. 5.

Quantification of α-CEHC glucuronide and γ-CEHC Glc in urine of wild-type and Pxr-null mice treated with vehicle (control) or PCN (50 mg/kg/day, i.p.) for 4 days. Concentrations of creatinine, α-CEHC glucuronide, and γ-CEHC Glc were determined from calibration curves of each metabolite. A: Creatinine-normalized concentration of α-CEHC glucuronide. B: Creatinine-normalized concentration of γ-CEHC Glc. Data were represented as mean value ± SD (n = 5∼7). The P-values were calculated by ANOVA with Bonferroni correction. *** P < 0.001 and ** P < 0.005 compared with control group of wild-type mice.