Fig. 6.

Quantification of α-CEHC glucuronide and γ-CEHC Glc in urine of PXR-humanized and Pxr-null mice fed either purified diet (control) or diet containing rifampicin (RIF) for 4 weeks. Concentrations of creatinine, α-CEHC glucuronide, and γ-CEHC Glc were determined from calibration curves of each metabolite. A: Creatinine-normalized concentration of α-CEHC glucuronide. B: Creatinine-normalized concentration of γ-CEHC Glc. Data were represented as mean value ± SD (n = 5 for control, n = 8 for RIF of hPXR mice, n = 3 for control, n = 4 for RIF of Pxr-null mice). The P-values were calculated by ANOVA with Bonferroni correction. * P < 0.01 compared with control group of PXR-humanized mice.