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Proposed major metabolic pathways of vitamin E in wild-type mice with PXR activation. Activation of PXR increases hepatic ω-oxidation by increasing expression of ω-oxidation-related genes such as Cyp3a11 but represses peroxisomal β-oxidation by decreasing Scp2 expression, resulting in attenuated concentration of α-CEHC glucuronide and γ-CEHC Glc in urine.
