TABLE 1.
Body weight, liver weight, food consumption, fat absorption, and serum and hepatic lipid profile of LD-fed wild-type and L-Fabp−/− mice
| Parameters | Wild Type | L-Fabp−/− | P |
|---|---|---|---|
| Body weight (g) | 22.7 ± 0.3 (22) | 20.1 ± 0.5 (21) | ** |
| Weight gain (g) | −0.9 ± 0.2 (22) | −1.9 ± 0.3 (21) | ** |
| Liver weight (g) | 1.4 ± 0.04 (22) | 1.3 ± 0.06 (21) | * |
| Liver weight (% body weight) | 6.3 ± 0.2 (22) | 6.3 ± 0.2 (21) | NS |
| Fat absorption (%) | 93.9 ± 0.3 (4) | 93.6 ± 0.4 (4) | NS |
| Feed efficiency | −23.7 ± 9.2 (4) | −50.6 ± 8.6 (4) | NS |
| Serum cholesterol (mg/dl) | 167.2 ± 8.0 (13) | 241.3 ± 29.5 (13) | * |
| Serum TG (mg/dl) | 10.1 ± 1.3 (8) | 12.2 ± 2.2 (8) | NS |
| Serum phospholipids (mg/dl) | 204.3 ± 7.8 (8) | 208.2 ± 13 (8) | NS |
| Serum FFAs (mmol/l) | 0.24 ± 0.04 (8) | 0.26 ± 0.09 (8) | NS |
| Serum glucose (mg/dl) | 174.5 ± 8.0 (13) | 128.7 ± 8.3 (13) | ** |
| Serum BA (μmol/L) | 15.9 ± 2.0 (8) | 33.8 ± 2.0 (8) | * |
| Serum ALT (IU/L) | 74.4 ± 16.4 (13) | 117.7 ± 13.0 (13) | * |
| Hepatic total cholesterol (μg/mg protein) | 210.2 ± 10.3 (8) | 232.7 ± 20.3 (8) | NS |
| Hepatic free cholesterol (μmol/mg protein) | 31.96 ± 1.73 (8) | 45.20 ± 3.1 (8) | * |
| Hepatic cholesterol ester (μmol/mg protein) | 178.2 ± 11.1 (8) | 187.5 ± 21.4 (8) | NS |
| Hepatic TG (μg/mg protein) | 120.7 ± 10.8 (8) | 83.9 ± 6.6 (8) | ** |
| Hepatic phospholipid (μg/mg protein) | 98.5 ± 1.7 (8) | 123.4 ± 4.9 (8) | ** |
| Hepatic FFA (nmol/mg protein) | 33.9 ± 1.6 (8) | 37.0 ± 3.7 (8) | NS |
Values represent the mean ± SE (n). ALT, alanine aminotransferase; NS, not significant. Feed efficiency is milligrams of weight change per gram of food consumed. *P < 0.05; **P < 0.01.