TABLE 2.

Liver microarray data: LD

Gene Name	Gene Description	Accession Number	Ratioa	qRT-PCR	P
BA synthesis, transport, and metabolism
Cyp7a1	Cholesterol 7α-hydroxylase	NM_007824	0.21	0.43	*
Cyp27a1	Sterol 27-hydroxylase	NM_024264	0.97	1.03
Cyp8b1	Sterol 12α-hydroxylase	NM_010012	0.27	0.14
Bsep/Abcb11	Bile salt export pump	NM_021022	1.80	1.01
Ntcp	Na+-taurocholate cotransporting protein	NM_011387	1.20	0.85
Oatp4	Organic anion transporter, 1b2	NM_178235	1.60	1.14
Oatp2	Organic anion transporter, 1a4	NM_030687	2.00	1.51	*
Ostb	Organic solute transporter β	NM_178933	2.00	2.49	**
Mdr3/Abcb4	ATP binding cassette, B4	NM_008830	2.80	1.41	*
Mrp2/Abcc2	ATP binding cassette, C2	NM_013806	1.30	0.92
Cyp2b10	Cytochrome P450, 2b10	NM_009998	0.82
Cyp3a11	Cytochrome P450, 3a11	NM_007818	3.00
Cholesterol synthesis, esterification, and transport
Hmgcr	HMG-CoA reductase	NM_008255	1.60	1.53	*
Abca1	ATP binding cassette, A1	NM_013454	1.80	1.28	*
Abcg5	ATP binding cassette, G5	NM_031884	1.90	1.07
Abcg8	ATP binding cassette, G8	NM_026180	1.20	1.31
Abcg1	ATP binding cassette, G1	NM_009593	0.70	0.50	**
Acat1	Acetyl-CoA acetyltransferase 1	NM_009230	0.43	0.29	**
Acat2	Acetyl-CoA acetyltransferase 2	NM_146064	1.25	1.42
Cd36	FA translocase	NM_007643	0.85	0.84
Srb1	Scavenger receptor class, B1	NM_016741	1.20	0.83
Scp2	Sterol carrier protein 2, liver	NM_011327	1.29	0.93
CAV1	Caveolin 1	NM_007616	1.00
NPC1	Niemann pick type C1	NM_008720	1.27
StarD4	StAR-related lipid transfer domain containing 4	NM_133774	2.00	1.48
Transcription factors or nuclear receptors
Lxrα	Liver X receptor	NM_013839	1.00	0.77
Fxr	Farnesoid X receptor	NM_009108	1.50	0.95
Shp	Small heterodimer partner	NM_011850	1.60	1.28
Pparα	Peroxisome proliferator activated receptor α	NM_011144	1.60	1.54	*
Srebp1	Sterol regulatory element binding protein 1	NM_011480	2.50	2.36	*
Srebp2	Sterol regulatory element binding protein 2	NM_033218	0.90	0.86
Rxr	Retinoid X receptor, α	NM_011305	1.60	1.14
FgfR4	Fibroblast growth factor receptor 4	AF127140	1.10	1.11
Hnf4a	Hepatic nuclear factor 4, α	NM_008261	1.50	1.03
FA synthesis and oxidation
Fasn	Fatty acid synthase	NM_007988	5.40	3.80	*
Ucp2	Uncoupling protein 2	NM_011671	0.83
Scd1	Stearoyl-CoA desaturase 1	NM_009127	3.40	0.93
Scd2	Stearoyl-CoA desaturase 2	NM_009128	0.80
Acaa1	Acetyl-CoAacyltransferase 1	NM_130864	2.19	5.62	*
Acadl	Acyl-CoA dehydrogenase, long chain	NM_007381	2.13	1.61
Acot1	Acyl-CoA thioesterase 1	NM_012006	9.33	4.85	**
Lipoprotein metabolism
apoB	Apolipoprotein B	XM_137955	1.13
apoA4	Apolipoprotein A-IV	NM_007468	2.00	1.94	*
apoC3	Apolipoprotein C-III	NM_023114	1.80
apoC2	Apolipoprotein C-II	NM_009695	1.90
Ldlr	LDL receptor	NM_010700	1.40	1.70
Vldlr	VLDL receptor	NM_013703	1.60	1.30
ApoA1	Apolipoprotein A	NM_009692	1.70	1.12
apoE	Apolipoprotein E	NM_009696	1.70	0.92
apoA5	Apolipoprotein A-V	NM_080434	1.30	1.93
Mttp	Microsomal TG transfer protein	NM_008624	1.40	2.06	**
others
Cyp4a14	Cytochrome P450, 4A14	NM_007822	34.40	26.55	**

Relative expression of some genes was confirmed by real time qRT-PCR by individual samples (four mice per group). qRT-PCR results were expressed as a fold change normalized to the wild-type control. *P < 0.05; **P < 0.01.

^aMicroarray data are expressed as an expression ratio of L-Fabp^−/− versus the wild type.