Table 1.

Kaplan-Meier analysis of the effect of genotype on overall survival: all patients

Variant	Median Overall Survival (± SE, months)			Log Rank (2 degrees of freedom)
MTHFR c.677C>T	CC: 10 ± 1	CT: 10 ± 1	TT: 7 ± 3	9.21, p = 0.010
MTHFR c.1298A>C	AA: 10 ± 1	AC: 9 ± 1	CC: 14 ± 4	0.60, p = 0.742
MTR c.2756A>G	AA: 10 ± 1	AG: 9 ± 1	GG: 8 ± 5	0.07, p = 0.967
Tc2 c.776C>G	CC: 8 ± 2	CG: 10 ± 1	GG: 9 ± 2	1.52, p = 0.469

Abbreviations: MTHFR, 5,10-methylenetetrahydrofolate reductase; MTR, 5-methyltetrahydrofolate-homocysteine S-methyltransferase; Tc2, transcobalamin 2. Owing to multiple testing, the threshold was defined with α = 0.0125. Censored for MTHFR c.677C>T: CC, n = 9; CT, n = 6; TT, n = 0.