Schedule of the BSG 98 prospective protocol. Abbreviations: Tamox, tamoxifen; HD-MTX, high-dose methotrexate; SD, stable disease; PD, progressive disease; RT, radiotherapy. Modified Grossmann refers to treatment of continuous infusion of BCNU and cisplatin based on Grossman et al.,36 as modified here (see “Materials and Methods”). *Tamoxifen was omitted in latest patients.