Table 1.
Drug dosing and schedule for the BSG 98 prospective protocol
| Day
|
|||||
|---|---|---|---|---|---|
| Treatment | 1 | 2 | 3 | 4 | 5 |
| Modified Grossman course 1a | |||||
| Tamoxifenb | 100 mg/m2 | 20 mg/m2 | 20 mg/m2 | 20 mg/m2 | 20 mg/m2 |
| BCNU 24-h continuous infusion | 40 mg/m2 | 40 mg/m2 | 40 mg/m2 | 40 mg/m2 | |
| CDDP 24-h continous infusion | 40 mg/m2 | 40 mg/m2 | 40 mg/m2 | 40 mg/m2 | |
| Courses 2 and 3: high-dose MTX | |||||
| MTX 3-h continuous infusion | 12 g/m2 | ||||
| Folinate rescue each 6 h | 15 mg/m2/6 h | 15 mg/m2/6 h | 15 mg/m2/6 h | ||
| Chemotherapy during and after RT | |||||
| Hydroxyurea | 20 mg/kg/day until progression | ||||
| Tamoxifenb | 20 mg/kg/day until during RT | ||||
Abbreviations: BCNU, bis(2-chloroethyl)-1-nitrosourea; CDDP, cisplatin; MTX, methotrexate; RT, radiotherapy.
a
Modified Grossmann refers to treatment of continuous infusion of BCNU and cisplatin based on Grossman et al., 36 as modified here (see “Materials and Methods”).
b
Tamoxifen was omitted in the latest patients.