Table 3.
Odds ratios for oxidative stress gene single nucleotide polymorphisms in non-Hispanic whites in the National Cancer Institute Adult Brain Tumor Study, 1994–1998 (adjusted for age, sex, study site, distance of residence from hospital)
| Glioma
|
Meningioma
|
Acoustic Neuroma
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene Polymorphism | Chromosomal Location | Genotype | Controls (n) | n | OR (95% CI) | n | OR (95% CI) | n | OR (95% CI) |
| CAT rs1001179 | 11p13 | CC | 251 | 195 | 1.0 (ref) | 73 | 1.0 (ref) | 43 | 1.0 (ref) |
| CT | 164 | 124 | 1.0 (0.7, 1.4) | 39 | 0.8 (0.5, 1.2) | 17 | 0.5 (0.3, 1.0) | ||
| TT | 23 | 11 | 0.6 (0.3, 1.3) | 8 | 1.2 (0.5, 3.0) | 3 | 0.7 (0.2, 2.7) | ||
| p-trend = 0.5 | p-trend = 0.6 | p-trend = 0.1 | |||||||
| CT or TT | 187 | 135 | 1.0 (0.7, 1.3) | 47 | 0.8 (0.5, 1.3) | 20 | 0.6 (0.3, 1.0)* | ||
| CC or CT | 415 | 319 | 1.0 (ref) | 112 | 1.0 (ref) | 60 | 1.0 (ref) | ||
| TT | 23 | 11 | 0.6 (0.3, 1.3) | 8 | 1.4 (0.6, 3.3) | 3 | 0.9 (0.3, 3.4) | ||
| CAT rs769214 a | 11p13 | AA | 208 | 158 | 1.0 (ref) | 52 | 1.0 (ref) | 28 | 1.0 (ref) |
| AG | 219 | 156 | 0.9 (0.7, 1.2) | 61 | 1.1 (0.7, 1.8) | 28 | 0.9 (0.5, 1.7) | ||
| GG | 33 | 24 | 1.0 (0.5, 1.7) | 7 | 0.9 (0.3, 2.1) | 6 | 1.2 (0.4, 3.1) | ||
| p-trend = 0.7 | p-trend = 0.9 | p-trend = 1.0 | |||||||
| AG or GG | 252 | 180 | 0.9 (0.7, 1.2) | 68 | 1.1 (0.7, 1.7) | 34 | 1.0 (0.5, 1.7) | ||
| AA or AG | 427 | 314 | 1.0 (ref) | 113 | 1.0 (ref) | 56 | 1.0 (ref) | ||
| GG | 33 | 24 | 1.0 (0.6, 1.8) | 7 | 0.8 (0.3, 1.9) | 6 | 1.2 (0.5, 3.1) | ||
| GPX1 rs1050450 | 11q13 | CC | 236 | 165 | 1.0 (ref) | 57 | 1.0 (ref) | 28 | 1.0 (ref) |
| CT | 178 | 140 | 1.1 (0.8, 1.5) | 56 | 1.2 (0.8, 1.9) | 30 | 1.4 (0.8, 2.4) | ||
| TT | 46 | 35 | 1.0 (0.6, 1.7) | 10 | 0.9 (0.4, 2.0) | 7 | 1.5 (0.6, 3.8) | ||
| p-trend = 0.7 | p-trend = 0.7 | p-trend = 0.3 | |||||||
| CT or TT | 224 | 175 | 1.1 (0.8, 1.4) | 66 | 1.2 (0.8, 1.8) | 37 | 1.4 (0.8, 2.4) | ||
| CC or CT | 414 | 305 | 1.0 (ref) | 113 | 1.0 (ref) | 58 | 1.0 (ref) | ||
| TT | 46 | 35 | 1.0 (0.6, 1.6) | 10 | 0.8 (0.4, 1.8) | 7 | 1.3 (0.5, 3.1) | ||
| GPX1 rs1800668 | 11q13 | CC | 218 | 156 | 1.0 (ref) | 56 | 1.0 (ref) | 27 | 1.0 (ref) |
| CT | 171 | 132 | 1.1 (0.8, 1.5) | 52 | 1.1 (0.7, 1.7) | 29 | 1.3 (0.7, 2.3) | ||
| TT | 50 | 40 | 1.1 (0.7, 1.7) | 12 | 0.9 (0.4, 1.9) | 7 | 1.3 (0.5, 3.3) | ||
| p-trend = 0.7 | p-trend = 1.0 | p-trend = 0.4 | |||||||
| CT or TT | 221 | 172 | 1.1 (0.8, 1.4) | 64 | 1.1 (0.7, 1.6) | 36 | 1.3 (0.7, 2.2) | ||
| CC or CT | 389 | 288 | 1.0 (ref) | 108 | 1.0 (ref) | 56 | 1.0 (ref) | ||
| TT | 50 | 40 | 1.0 (0.7, 1.6) | 12 | 0.9 (0.4, 1.8) | 7 | 1.2 (0.5, 2.8) | ||
| NOS3 rs1799983 | 7q36 | GG | 204 | 157 | 1.0 (ref) | 52 | 1.0 (ref) | 33 | 1.0 (ref) |
| GT | 202 | 148 | 1.0 (0.7, 1.3) | 57 | 1.0 (0.6, 1.6) | 25 | 0.7 (0.4, 1.4) | ||
| TT | 61 | 35 | 0.7 (0.5, 1.2) | 14 | 0.8 (0.4, 1.6) | 5 | 0.5 (0.2, 1.5) | ||
| p-trend = 0.3 | p-trend = 0.7 | p-trend = 0.2 | |||||||
| GT or TT | 263 | 183 | 0.9 (0.7, 1.2) | 71 | 1.0 (0.6, 1.5) | 30 | 0.7 (0.4, 1.2) | ||
| GG or GT | 406 | 305 | 1.0 (ref) | 109 | 1.0 (ref) | 58 | 1.0 (ref) | ||
| TT | 61 | 35 | 0.8 (0.5, 1.2) | 14 | 0.8 (0.4, 1.6) | 5 | 0.6 (0.2, 1.6) | ||
| PON1 rs662 a | 7q21 | AA | 244 | 163 | 1.0 (ref) | 74 | 1.0 (ref) | 29 | 1.0 (ref) |
| AG | 165 | 143 | 1.3 (0.9, 1.7) | 37 | 0.7 (0.4, 1.1) | 27 | 1.5 (0.8, 2.7) | ||
| GG | 44 | 26 | 0.9 (0.5, 1.5) | 9 | 0.7 (0.3, 1.6) | 4 | 0.8 (0.2, 2.4) | ||
| p-trend = 0.6 | p-trend = 0.2 | p-trend = 0.7 | |||||||
| AG or GG | 209 | 169 | 1.2 (0.9, 1.6) | 46 | 0.7 (0.5, 1.1) | 31 | 1.3 (0.7, 2.3) | ||
| AA or AG | 409 | 306 | 1.0 (ref) | 111 | 1.0 (ref) | 56 | 1.0 (ref) | ||
| GG | 44 | 26 | 0.8 (0.5, 1.3) | 9 | 0.8 (0.4, 1.8) | 4 | 0.6 (0.2, 1.9) | ||
| SOD1 rs2070424 | 21q22 | AA | 414 | 303 | 1.0 (ref) | 112 | 1.0 (ref) | 60 | 1.0 (ref) |
| AG | 55 | 37 | 0.9 (0.6, 1.4) | 12 | 0.7 (0.4, 1.5) | 4 | 0.4 (0.1, 1.3) | ||
| GG | 0 | 2 | — | 0 | — | 1 | — | ||
| p-trend = 0.9 | p-trend = 0.4 | p-trend = 0.5 | |||||||
| AG or GG | 55 | 39 | 0.9 (0.6, 1.4) | 12 | 0.7 (0.4, 1.5) | 5 | 0.6 (0.2, 1.5) | ||
| AA or AG | 469 | 340 | 1.0 (ref) | 124 | 1.0 (ref) | 64 | 1.0 (ref) | ||
| GG | 0 | 2 | — | 0 | — | 1 | — | ||
| SOD2 rs4880 | 6q25 | TT | 122 | 80 | 1.0 (ref) | 39 | 1.0 (ref) | 10 | 1.0 (ref) |
| CT | 220 | 167 | 1.1 (0.8, 1.6) | 61 | 0.9 (0.6, 1.5) | 34 | 2.1 (1.0, 4.5) | ||
| CC | 109 | 86 | 1.1 (0.8, 1.7) | 21 | 0.6 (0.3, 1.1) | 16 | 1.9 (0.8, 4.6) | ||
| p-trend = 0.5 | p-trend = 0.1 | p-trend = 0.2 | |||||||
| CT or CC | 329 | 253 | 1.1 (0.8, 1.6) | 82 | 0.8 (0.5, 1.3) | 50 | 2.0 (1.0, 4.2)* | ||
| TT or CT | 342 | 247 | 1.0 (ref) | 100 | 1.0 (ref) | 44 | 1.0 (ref) | ||
| CC | 109 | 86 | 1.1 (0.8, 1.5) | 21 | 0.6 (0.4, 1.1) | 16 | 1.1 (0.6, 2.2) | ||
| SOD3 rs699473 | 4p15 | TT | 210 | 134 | 1.0 (ref) | 41 | 1.0 (ref) | 32 | 1.0 (ref) |
| CT | 204 | 166 | 1.3 (0.95, 1.7) | 65 | 1.7 (1.1, 2.7)* | 31 | 1.0 (0.5, 1.7) | ||
| CC | 48 | 38 | 1.2 (0.7, 2.0) | 17 | 2.1 (1.0, 4.1)* | 2 | — | ||
| p-trend = 0.2 | p-trend = 0.01* | p-trend = 0.1 | |||||||
| CT or CC | 252 | 204 | 1.3 (1.0, 1.7)* | 82 | 1.7 (1.1, 2.7)* | 33 | 0.8 (0.5, 1.4) | ||
| TT or CT | 414 | 300 | 1.0 (ref) | 106 | 1.0 (ref) | 63 | 1.0 (ref) | ||
| CC | 48 | 38 | 1.1 (0.7, 1.7) | 17 | 1.6 (0.8, 3.0) | 2 | — | ||
Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval; ref, reference group.
a
Controls not in Hardy-Weinberg equilibrium (p = 0.04 for PON1 rs662, p = 0.02 for CAT rs769214).
*
Significant (or borderline significant) at the p < 0.05 level.