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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Europace. 2008 May 30;10(7):868–876. doi: 10.1093/europace/eun138

Figure 3.

Figure 3

Ab-β modulate M cell action potential by activating beta-adrenergic receptor. Transmembrane activity recorded from M cells isolated from the guinea pig left ventricle. Recordings were obtained at a BCL of 1000 ms under steady-state conditions, during Ab-β (Ab-β: 1/100 V/V) perfusion, and after washout (A). In (B), the presence of atenolol (1 μM) inhibited the effect mediated by Ab-β. Sera from chronic chagasic patients without adrenergic effect (Ab-: 1/100 V/V) did not modulate the APD of guinea pig M cells at a BCL of 1000 ms. (C) APD90 modulation by Ab- (n = 6) or Ab-β (n = 7) under different rates is summarized in (D). Values are mean ± SEM. *P < 0.05 and #P < 0.005.