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IgG-β does not modulate Ito. Representative current traces of Ito under control and isoproterenol (1 μM) perfusion (A) and under control and IgG-β (24μg/mL) perfusion (B) are superimposed. Current–voltage curves show that neither isoproterenol (P > 0.05 and n = 5) nor IgG-β (P > 0.05 and n = 7) modulated Ito current (right panels). IgG-β did not modulate the kinetics or voltage dependence of Ito channel activation (C). Values are mean ± SEM.
