Table 1.
(ms) | 300 | 500 | 800 | 1000 | 2000 |
---|---|---|---|---|---|
RMP (-mV) | |||||
Control | 79.2 ± 3.7 | 80.3 ± 3.3 | 80.3 ± 3.2 | 79.3 ± 3.2 | 79.4 ± 3.1 |
Ab-β (n = 7) | 80.8 ± 3.9 | 81.1 ± 3.7 | 80.7 ± 3.6 | 80.2 ± 3.3 | 79.1 ± 3.1 |
Phase 0 amplitude (mV) | |||||
Control | 121.6 ± 1.5 | 122.5 ± 1.6 | 123.6 ± 1.3 | 124.0 ± 1.4 | 124.8 ± 1.5 |
Ab-β | 120.1 ± 3.5 | 122.3 ± 2.7 | 123.0 ± 2.5 | 123.0 ± 2.6 | 123.2 ± 2.9 |
APD90 (ms) | |||||
Control | 148.8 ± 3.8* | 166.1 ± 4.2 | 176.0 ± 3.5 | 179.4 ± 2.5* | 178.7 ± 3.9 |
Ab-β | 135.1 ± 3.1* | 162.6 ± 4.7 | 167.9 ± 2.8 | 170.3 ± 2.2* | 173.5 ± 1.6 |
APD30 (ms) | |||||
Control | 64.2 ± 4.9 | 76.2 ± 4.9 | 82.1 ± 3.4 | 89.1 ± 3.1 | 92.7 ± 3.1 |
Ab-β | 56.9 ± 4.2 | 71.5 ± 3.5 | 82.5 ± 1.9 | 84.1 ± 3.2 | 90.6 ± 2.3 |
RMP (-mV) | |||||
Control | 86.3 ± 2.9 | 86.1 ± 3.0 | 86.1 ± 3.2 | 85.1 ± 3.2 | 83.4 ± 3.1 |
Ab- (n = 8) | 85.3 ± 2.7 | 84.9 ± 2.8 | 85.0 ± 3.0 | 84.5 ± 2.8 | 85.2 ± 2.9 |
Phase 0 amplitude (mV) | |||||
Control | 121.1 ± 1.8 | 122.3 ± 1.7 | 123.4 ± 1.6 | 123.2 ± 1.7 | 124.6 ± 1.9 |
Ab- | 121.3 ± 2.6 | 123.5 ± 2.5 | 124.7 ± 2.5 | 125.3 ± 2.6 | 126.5 ± 2.2 |
APD90 (ms) | |||||
Control | 136.7 ± 6.7 | 153.6 ± 6.8 | 162.3 ± 6.8 | 167.5 ± 7.8 | 166.1 ± 7.2 |
Ab- | 133.5 ± 7.2 | 152.0 ± 7.5 | 159.6 ± 8.3 | 162.8 ± 8.3 | 160.2 ± 8.0 |
APD30 (ms) | |||||
Control | 63.9 ± 2.6 | 72.8 ± 3.6 | 85.7 ± 3.2 | 90.7 ± 3.9 | 92.9 ± 3.7 |
Ab- | 58.3 ± 3.9 | 70.7 ± 4.6 | 79.7 ± 3.7 | 85.5 ± 3.4 | 90.1 ± 3.2 |
BCL, basic cycle lengths; RMP, resting membrane potential; APD90, action potential duration at 90% repolarization; APD30, action potential duration at 30% repolarization;
P < 0.05, control vs. Ab-β. All values are expressed as mean ± SEM.